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Since monoamine oxidase A and B inhibitors also enhance the catecholaminergic pathwaysby a different mechanism from bupropionconcomitant use of Zyban and monoamine oxidase inhibitorsMAOIsis contraindicatedsee section 4.3as there is an increased possibility of adverse reactions from their co-administrationAt least 14 days should elapse between discontinuation of irreversible MAOIs and initiation of treatment with ZybanFor reversible MAOIsa 24 hour period is sufficient.

But varenicline also limits the effect of inhaled nicotine on these receptors tooSo if someone taking the medicine does smokethe nicotine inhaled will have little to no effect on receptors in the brainrendering the act of smoking chemically impotentThis consequently makes the act of smoking less desirable.

It is recommended that you do not try to quit smoking until you have been taking bupropion for 1 week so that the drug can reach a high enough level in your bloodSet a date for quittingand stop smoking sometime in the second week of taking the drug.

A very serious allergic reaction to this drug is unlikelybut seek immediate medical attention if it occursSymptoms of a serious allergic reaction includerashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathing.

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