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Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription herbal products you may use, especially of anti-platelet drugs, oral bisphosphonates, blood thinners , corticosteroids, cyclosporine, desmopressin, digoxin, high blood pressure drugs, lithium, methotrexate, pemetrexed, probenecid, ssri anti-depressants, water pills diuretics such as furosemide, hydrochlorothiazide, triamterene .

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Fluid and electrolyte imbalances are the most important concernExcessive doses of the triamterene component may elicit hyperkalemiadehydrationnauseavomiting and weakness and possibly hypotensionOverdosing with hydrochlorothiazide has been associated with hypokalemiahypochloremiahyponatremiadehydrationlethargymay progress to comaand gastrointestinal irritationTreatment is symptomatic and supportiveTherapy with MAXZIDEtriamterene and hydrochlorothiazideshould be discontinuedInduce emesis or institute gastric lavageMonitor serum electrolyte levels and fluid balance.

Whenever adverse reactions are moderate to severetherapy should be reduced or withdrawn.

Triamterene is used alone or with other medications to treat edemafluid retentionexcess fluid held in body tissuescaused by various conditionsincluding liver and heart diseaseTriamterene is in a class of medications called diureticswater pillsIt causes the kidneys to eliminate unneeded water and sodium from the body into the urinebut reduces the loss of potassium.

Cardiovasculartachycardiashortness of breath and chest painorthostatic hypotensionmay be aggravated by alcoholbarbiturates or narcotics

To reduce your risk of side effectsyour doctor may direct you to start this medication at a low dose and gradually increase your doseFollow your doctor’s instructions carefully.

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